The Common Fund’s 4D Nucleome program aims to understand the principles underlying nuclear organization in space and time, the role nuclear organization plays in gene expression and cellular function, and how changes in nuclear organization affect normal development as well as various diseases.
This program will develop technologies, resources and data to enable the study of the 4D Nucleome, including novel tools to explore the dynamic nuclear architecture and its role in gene expression programs, models to examine the relationship between nuclear organization and function in both normal development and disease, and reference maps of nuclear architecture in a variety of cells and tissues.
The NIH Common Fund 4D Nucleome program has released an RFI to solicit feedback from the national and international community on the remaining challenges towards a comprehensive analysis of the mammalian 4D Nucleome. Suggestions from all are welcome. Written responses must be submitted by August 6, 2018 to 4DNucleome@mail.nih.gov.