4D NucleomeTechnology - Resources - Data

4D Nucleome Aims to Understand the Principles Underlying Nuclear Organization

Working to understand the principles underlying nuclear organization in space and time, the role nuclear organization plays in gene expression and cellular function, and how changes in nuclear organization affect both normal development and various diseases.

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4D Nucleome Aims to Improve Public Health

The 4D Nucleome (4DN) Program explores the 3D organization of the DNA in the nucleus and how the organization changes over time (the fourth dimension). Exploring the 4D organization of DNA requires developing new tools to observe differences in the organization of DNA between different cells and how the genome organization in the nucleus of a single cell changes over time.

Program Overview

Data Portal

Hosting data generated by the 4DN Network and other reference nucleomics data sets, and an open data processing and visualization tool set.

Nucleome Browser

Nucleome Browser is a multimodal, interactive data visualization and exploration platform to integrate genomic, imaging, and 3D structure data.

Internal Wiki

The 4D Nucleome Network Wiki is an internal collaboration site, accessible to 4DN investigators and members only.

Member Directory

Directory for all 4DN members allowing logged in members to manage profiles and team members' profiles, participate in the working groups, and more.

4DN Phase II Funded Research Announcements

The 3D Genome - Nature Reviews: Molecular Cell Biology

Mapping the Structure of Genomes in Space and Time

Tweets by 4DNucleome

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4D Nucleome News

FOLLOW THE 4D NUCLEOME DATA ACROSS THE ENTIRE NETWORK

Latest 4DN News

2023 conference on “Structure, Function and Development of Neural Circuits”

The conference (August 21-23, 2023) will take place at the Beckman Center of the National Academies of Sciences & Engineering near the UC Irvine campus in Southern California and it will feature a 4DN workshop and additional events co-hosted by 4DN Consortium.... Read more

March 23, 2023

4DN News and Announcements

Blake Nolan

2023 4DN Annual Meeting

Save the date for the next 4D Nucleome Annual Meeting to be held in person on December 9-11, 2023 at Boston Park Plaza, in Boston, Massachusetts.... Read more

February 28, 2023

4DN News and Announcements

Blake Nolan

4D Nucleome Tutorial Series #2

“Multimodal Visualization for 4DN data using Nucleome Browser and OME” October 28, 2022 8AM – 9AM PST; Virtual on Zoom... Read more

October 21, 2022

4DN News and Announcements

Blake Nolan

Latest 4DN Publications

Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes

Mayank N. K. Choudhary, Kara Quaid, Xiaoyun Xing, Heather Schmidt & Ting Wang ... Read more

February 6, 2023

Latest 4DN Publications

An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

Parisha P. Shah, Kathleen C. Keough, Ketrin Gjoni, Garrett T. Santini, Richard J. Abdill, Nadeera M. Wickramasinghe, Carolyn E. Dundes, Ashley Karnay, Angela Chen, Rachel E. A. Salomon, Patrick J. Walsh, Son C. Nguyen, Sean Whalen, Eric F. Joyce, Kyle M. Loh, Nicole Dubois, Katherine S. Pollard & Rajan Jain ... Read more

January 23, 2023

Latest 4DN Publications

Optimized single-nucleus transcriptional profiling by combinatorial indexing

Beth K. Martin, Chengxiang Qiu, Eva Nichols, Melissa Phung, Rula Green-Gladden, Sanjay Srivatsan, Ronnie Blecher-Gonen, Brian J. Beliveau, Cole Trapnell, Junyue Cao & Jay Shendure ... Read more

January 18, 2023

Latest 4DN Publications