4D NucleomeTechnology - Resources - Data

4D Nucleome Aims to Understand the Principles Underlying Nuclear Organization

Working to understand the principles underlying nuclear organization in space and time, the role nuclear organization plays in gene expression and cellular function, and how changes in nuclear organization affect both normal development and various diseases.

4D Nucleome Aims to Improve Public Health

The 4D Nucleome (4DN) Program explores the 3D organization of the DNA in the nucleus and how the organization changes over time (the fourth dimension). Exploring the 4D organization of DNA requires developing new tools to observe differences in the organization of DNA between different cells and how the genome organization in the nucleus of a single cell changes over time.
Program Overview

4DN Phase II Funded Research Announcements

The 3D Genome - Nature Reviews: Molecular Cell Biology

Mapping the Structure of Genomes in Space and Time

Check The Latest
4D Nucleome Publications

Roger S. Zou, Alberto Marin-Gonzalez, Yang Liu, Hans B. Liu, Leo Shen, Rachel K. Dveirin, Jay X. J. Luo, Reza Kalhor, Taekjip Ha  Here we present an approach that combines a clustered regularly interspaced short palindromic repeats (CRISPR) system that simultaneously targets hundreds of epigenetically diverse endogenous genomic sites with high-throughput... Read more
September 5, 2022
Jennifer A. Karlow, Siddhartha Devarakonda, Xiaoyun Xing, Hyo Sik Jang, Ramaswamy Govindan, Mark Watson, Ting Wang Non–small cell lung cancer (NSCLC) is one of the most commonly diagnosed and deadliest cancers worldwide, with roughly half of all patients initially presenting with both primary and metastatic disease. While the major events in the metastatic cascade have been... Read more
August 3, 2022
Xiaopeng Zhu, Yang Zhang, Yuchuan Wang, Dechao Tian, Andrew S. Belmont, Jason R. Swedlow & Jian Ma The epigenomics community, including the NIH 4D Nucleome (4DN) Consortium, is generating numerous genomic and imaging datasets for studying nuclear structure and function. Integrating primary data with secondary analysis results will be required... Read more
July 20, 2022
Okafor, A. E., Lin, X., Situ, C., Wei, X., Wei, X., Wu, Z., Diao, Y.... Read more
September 17, 2022
Liu, B., Ni, P., Cai, L., Shi, X., Ji, S., Ke, Z., Zhang, S., Hu, B., Yang, B., Xu, Y., Long, W., Fang, Z., Hu, H., Wang, Y., Zhang, W., Geng, H., Xu, Y., Zheng, X., Wang, Z., Zhang, B., Pan, K., Zhou, K., Cui, Y., Wang, H., Liu, B.... Read more
August 28, 2022

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